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pentobarbital will lessen the level or effect of itraconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.pentobarbital will reduce the level or impact of finasteride by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unidentified.It is crucial to grasp what to do that